Prenatal Aneuploidy/NTD

Screening

Performed in:

Screens for:

First trimester Second trimester

Trisomy 21 Trisomy 18 Other chromosome Open neural

Abnormalities tube defect

Non-Invasive Prenatal Testing for Fetal

Aneuploidy (Panorama)

 * *

**Trisomy 13, triploidy, sex

chromosome abnormalites

Non-Invasive Prenatal Testing for

Fetal Aneuploidy (Panorama) with

Microdeletions

**

**Trisomy 13, triploidy, sex

chromosome abnormalities,

5 microdeletion syndromes

Maternal Serum Screen, First Trimester

*

**

Maternal Screening,

Sequential,Specimen #1*

**

Maternal Screening,*

Sequential,Specimen #2

Result based on first and second trimester samples

***

Maternal Serum Screening, Integrated,

Specimen #1

*

**

Maternal Serum Screening, Integrated,

Specimen #2

*

***

Maternal Serum Screen, Alpha

Fetoprotein, hCG, Estriol, and Inhibin A

*

***

Maternal Serum Screen, Alpha

Fetoprotein (Only)

*

*

Products of Conception Testing

Chromosome Analysis, Products of Conception

· Order for standard chromosome analysis performed on fetal tissue or villi

Chromosome Analysis, Products of Conception, with Reflex to

Genomic Microarray

· Useful to ensure the highest chance of obtaining meaningful results from POC specimens

· When tissue culture is unsuccessful or if the results of the chromosome analysis are normal, then testing reflexes to genomic microarray

Genomic SNP Microarray, Products of Conception (2005633)

· For the detection of copy number alterations and loss of heterozygosity in

unfixed fetal tissue or villi